Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand–dependent terminal keratinocyte differentiation
نویسندگان
چکیده
منابع مشابه
Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation
ADAM17 (a disintegrin and metalloproteinase 17) is ubiquitously expressed and cleaves membrane proteins, such as epidermal growth factor receptor (EGFR) ligands, l-selectin, and TNF, from the cell surface, thus regulating responses to tissue injury and inflammation. However, little is currently known about its role in skin homeostasis. We show that mice lacking ADAM17 in keratinocytes (A17(ΔKC)...
متن کاملADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phosholipase C γ1 and protein kinase C pathways
The vitally important skin barrier is formed by extensive cross-linking activity of transglutaminases (TGs) during terminal epidermal differentiation. We have previously shown that epidermal deficiency of a disintegrin and metalloproteinase 17 (ADAM17), the principal EGFR ligand sheddase, results in postnatal skin barrier defects in mice due to impeded TG activity. However, the mechanism by whi...
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BACKGROUND Defects in keratinocyte differentiation and skin barrier are important features of inflammatory skin diseases like atopic dermatitis. Mast cells and their main mediator histamine are abundant in inflamed skin and thus may contribute to disease pathogenesis. METHODS Human primary keratinocytes were cultured under differentiation-promoting conditions in the presence and absence of hi...
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Caspases are a family of cysteine proteases involved in the effector arm of physiologic cell death [1]. In 1998, a novel caspase designated ‘‘caspase 14’’ was described in embryonic and adult tissues, especially epidermal keratinocytes [2—4]. Unlike other caspases (such as 3, 6 and 7), caspase 14 is not processed by typical death stimuli or activated during apoptosis induced by ultraviolet irra...
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Although intercellular junctions are known to be the major regulators of permeability of simple epithelia, they had not been thought to be important in regulating the permeability of stratified mammalian epithelia. Furuse et al. (2002)(this issue) demonstrate that functional tight junctions may indeed be a necessary part of the permeability barrier of the skin.
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ژورنال
عنوان ژورنال: The Journal of Cell Biology
سال: 2012
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb1973oia7